Production of human IFN- .gamma. (immune) interferon

Details Production of human IFN- .gamma. (immune) interferon Production of human IFN- .gamma. (immune) interferon

1981-04-17

1983-03-15

Wiseman, Thomas G.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Enzymatic production of a protein or polypeptide

435240, 435811, C12P 2100, C12N 500

Patent

active

043768229

ABSTRACT:
A process is disclosed for producing human immune interferon with cell cultures of human peripheral blood leukocytes modulated with Mezerein or 12,13 phorbol dibutyrate and induced with Staphylococcal aureus enterotoxin B. After cultures are incubated for 3 to 7 days crude interferon on the order of 10.sup.3 units of interferon/ml. is produced.

REFERENCES:
Vilcek et al., in Yip et al., Stimulation of Human Gamma Interferon Production by Diterpene Esters J. of Immun., 1981, pp. 131-139, vol. 34, Ref. 32.
Langford et al., Biological Effects of SEA on Human Peripheral Lymphocytes J. of Immun., 1978, vol. 22, pp. 62-68.
Smith et al., The Effects of Staphylococcal Enterotoxins on the Primary in Vitro Immune Response Journal of Immun., 1975, vol. 115, pp. 575-578.
Epstein, The Effects of Interferons on the Immune Response in Vitro and in Vivo Interf. and Therhetions, 1977, CRC Press, Cleveland, pp. 114-121.

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