Production of human IFN-gamma (immune) interferon

Details Production of human IFN-gamma (immune) interferon Production of human IFN-gamma (immune) interferon

1981-04-17

1983-03-15

Wiseman, Thomas G.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Enzymatic production of a protein or polypeptide

435240, 435811, C12P 2100, C12N 500

Patent

active

043768210

ABSTRACT:
A process is disclosed for producing human immune interferon with cell cultures of human peripheral blood leukocytes modulated with Mezerein or 12, 13 phorbol dibutyrate and induced with the calcium ionophore A-23187. After cultures are incubated for 12 hours to about 7 days, crude interferon on the order of 10.sup.3 units of interferon/ml. is produced.

REFERENCES:
patent: 3923823 (1975-12-01), Gale et al.
Epstein, The Effects of Interferons on the Immune Response in vitro and in vivo, Interf. and Their Actions, 1977, CRC Press, Cleveland, pp. 114-121.
Vilcek in Yip et al., Stimulation of Human Gamma Interferon Production by Diterpene Esters, Inf. Immu., vol. 34, 1981, pp. 131-139-Ref. 32.
Dianzani et al., Human Immune Interferon:Induction in Lymphoid Cells by a Calcium Ionophore,Inf. & Immun., vol. 29, No. 2, 1980, pp. 561-563.

Affiliated with

Also associated with

Rating

Production of human IFN-gamma (immune) interferon does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Production of human IFN-gamma (immune) interferon, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Production of human IFN-gamma (immune) interferon will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1658725