Multicellular living organisms and unmodified parts thereof and – Method of introducing a polynucleotide molecule into or... – The polynucleotide alters fat – fatty oil – ester-type wax – or...
Patent
1997-03-31
1998-06-09
Rories, Charles C. P.
Multicellular living organisms and unmodified parts thereof and
Method of introducing a polynucleotide molecule into or...
The polynucleotide alters fat, fatty oil, ester-type wax, or...
800DIG9, 800DIG42, 800DIG43, 800DIG56, 435 691, 435 696, 435 697, 4351721, 4351723, 4353201, 435375, 435419, 530364, 536 235, C12N 500, C12N 1514, C12N 1582, A01H 500
Patent
active
057637482
ABSTRACT:
This invention provides for a method to produce excreted and correctly processed heterologous protein-material in a plant host. The method comprises the step of transforming a plant host using a recombinant polynucleotide, which comprises the DNA sequences encoding the fully processed heterologous protein material, directly preceded by a DNA sequence coding for a plant signal peptide, and regulatory sequences necessary for the plant host to express the heterologous gene construct, resulting in excretion of the heterologous protein from the cell and correct cleavage of the N-terminal signal peptide, so that the mature heterologous protein produced by the plant host is identical to the corresponding protein produced in its authentic host.
REFERENCES:
patent: 4956282 (1990-09-01), Goodman et al.
patent: 5650307 (1997-07-01), Sijmons et al.
B. Alberts et al., Molecular Biol. of the Cell, Garland Publ., Inc., NY, 1983, pp. 194-213, '83.
K. Barton et al., Plant Physiology, vol. 85, pp. 1103-1109 (1987).
Carlson et al., Cell, vol. 28, pp. 145-154 (1982).
Chen et al., EMBO Jounal, vol. 4, pp. 2145-2151 (1985).
B. Cornelissen et al., "A TMV-induced Tobacco Protein . . . ", Nature, vol. 321, pp. 531-532 (1986).
G. Della-Cioppa et al., "Protein Trafficking in Plant Cells,"Plant Physiology, vol. 34, pp. 965-968 (1987).
De Loose et al., Gene, vol. 70, pp. 13-23 (1988).
R. E. Dickerson et al., "The Structure and Action of Proteins", Menlo Park, CA, Benjamin/Cummings, (1969), pp. 59-66, 82-86.
Dorel et al., J. Cell. Biol., vol. 108, pp. 327-337 (1989).
Dorel et al., Plant Physiology (Abstract), vol. 86 (4 Suppl.)(88), p. 84.
Harkki et al., Bio/Technol., vol. 7, pp. 596-601 (1989).
Herskowitz et al., The Molecular Biology of the Yeast Saccharomyces, vol. 1, pp. 181-210 (1982).
L. Hoffman et al., Plant Mol. Biol., vol. 11, pp. 717-729 (1988).
Hooft van Huijsduijnen et al., EMBO Journal, vol. 4, pp. 2167-2171 (1985).
G. Iturriaga et al., The Plant Cell, vol. 1, pp. 381-390 (1989).
Johnsson et al., Cell., vol. 48, pp. 875-885 (1987).
Kingsman et al., Trends in Biotechnology, vol. 5, pp. 53-56 (1987).
Kornfeld, Fed. Am. Soc. Exp. Biol. Journal, vol. 1, pp. 462-468 (1987).
B. Larkins et al., J. Cell Biochem.; Supp. O, (9 Part C) (1985), p. 264.
Memelink, Altered Gene Expression in T-DNA Transformed Tobacco Tissues, Thesis, Rijksuniversiteit, Leiden, (1988), pp. 4-6, 97.
Misra, Plant Physiol., vol. 89:S47 (abstract No. 279) (1989).
T. Ohtani et al., Plant Mol. Biol., vol. 16, pp. 117-128 (1991).
R. Palmiter et al., "Cell Lineage Ablition in Transgenic Mice . . . ", Cell, vol. 50, pp. 435-443 (1987).
Passiatore et al., J. Cell. Biol., Suppl. BD p. 267 (abstract M145).
D. Perlman et al., A Putative Signal Peptidase Recognition Site . . . , Journal of Mol. Biol., vol. 167, pp. 391-409 (1983).
Pfeffer et al., Ann. Rev. Biochem., vol. 56, pp. 829-852 (1987).
Stetler et al., Bio/Technol., vol. 7, pp. 55-60 (1989).
Talmadge et al., Proc. Natl. Acad. Sci., vol. 77, pp. 3369-3373 (1980).
R. Vander Haar et al., "Organization of the Sunflower 11S Storage Protein Gene Family," Gene, vol. 74, pp. 433-443 (1988).
Villa-Komaroff et al., Proc. Natl. Acad. Sci. USA, vol. 75, pp. 3727-3731 (1987).
G. von Heijne, "How Signal Sequences Maintain Cleavage Specificity," Journal of Mol. Biol., vol. 173, pp. 243-251 (1984).
E. Weber et al., Carlsburg Res. Commun., vol. 50, pp. 299-308 (1985).
Dekker Bernardus Martinus M.
Hoekema Andreas
Schrammeijer Barbara
Sijmons Peter Christiaan
Van Den Elzen Peturs Josephus M.
Mogen International N.V.
Rories Charles C. P.
LandOfFree
Production of heterologous protein in plants and plant cells does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Production of heterologous protein in plants and plant cells, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Production of heterologous protein in plants and plant cells will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2201863