Chemistry: molecular biology and microbiology – Virus or bacteriophage – except for viral vector or... – Recovery or purification
Patent
1985-02-04
1988-01-26
Tarcza, John E.
Chemistry: molecular biology and microbiology
Virus or bacteriophage, except for viral vector or...
Recovery or purification
435235, 435948, 43524021, 424 89, C12N 702, C12N 700, C12N 500, A61K 3929
Patent
active
047216751
ABSTRACT:
The present invention relates to a method for producing human hepatitis A virus in vitro employing tissue culture techniques. In particular, the present invention relates to an in vitro tissue culture procedure utilizing a persistently infected cell line that produces high titers of hepatitis A virus. The hepatitis A virus thus produced is a source of hepatitis A virus antigens.
REFERENCES:
patent: 4102996 (1978-07-01), McAleer et al.
patent: 4164565 (1979-08-01), Prince et al.
patent: 4164566 (1979-08-01), Provost et al.
patent: 4344935 (1982-08-01), Leclerc et al.
patent: 4393133 (1983-07-01), Knowles et al.
patent: 4412002 (1983-10-01), McAleer et al.
Siegl et al, "The Physiochemical Properties of Infectious Hepatitis A Virons" Journal of General Virology 37 (1981) pp. 331-341.
Gauss-Muller et al., "Propagation of Hepatitis A Virus in Human Fibroblasts" Journal of Medical Virology 7(3) (1981) pp. 233-239.
Kojima et al. "Propagation of Human Hepatitis A Virus in Conventional Cell Lines" Journal of Medical Virology 7(4) pp. 273-286 (1981) Abstract only.
Flehmig, "Hepatitis A Virus in Cell Culture. II. Growth Characteristics of Hepatitis A Virus in Frhk-4/R Cells" Medical Microbiology and Immunology 170(2) (1981) pp. 73-81.
Aden et al, "Controlled Synthesis of HBsAg in a Differentiated Human Liver Carcinoma-Derived Cell Line" Nature 282 (12-1979) pp. 615-616.
Frosner et al, "Propagation of Human Hepatitis A Virus in a Hepatoma Cell Line" Abstracts of the Annual Meeting ASM (5-1980) abstract #S 57.
Siegl et al, "Propagation of Human Hepatitis A Virus in Hepatoma Cell Cultures" Experientia 30 (1980) p. 1448.
Frosner et al, "Propagation of Human Hepatitis A Virus in a Hepatoma Cell Line" Workshop of the Virology Section of the DGHM, Zentralblatt Fhur Bakteriologie, Parasitenkunde, Infekitionskrankheiten Und Hygine. vol. 248(1) (1980) pp. 15-16.
Chan Emerson W.
Mitchen Joel R.
Abbott Laboratories
Katz Martin L.
Tarcza John E.
LandOfFree
Production of hepatitis A virus in vitro utilizing a persistentl does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Production of hepatitis A virus in vitro utilizing a persistentl, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Production of hepatitis A virus in vitro utilizing a persistentl will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1467892