Production of hepatitis A virus in vitro utilizing a persistentl

Chemistry: molecular biology and microbiology – Virus or bacteriophage – except for viral vector or... – Recovery or purification

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

435235, 435948, 43524021, 424 89, C12N 702, C12N 700, C12N 500, A61K 3929

Patent

active

047216751

ABSTRACT:
The present invention relates to a method for producing human hepatitis A virus in vitro employing tissue culture techniques. In particular, the present invention relates to an in vitro tissue culture procedure utilizing a persistently infected cell line that produces high titers of hepatitis A virus. The hepatitis A virus thus produced is a source of hepatitis A virus antigens.

REFERENCES:
patent: 4102996 (1978-07-01), McAleer et al.
patent: 4164565 (1979-08-01), Prince et al.
patent: 4164566 (1979-08-01), Provost et al.
patent: 4344935 (1982-08-01), Leclerc et al.
patent: 4393133 (1983-07-01), Knowles et al.
patent: 4412002 (1983-10-01), McAleer et al.
Siegl et al, "The Physiochemical Properties of Infectious Hepatitis A Virons" Journal of General Virology 37 (1981) pp. 331-341.
Gauss-Muller et al., "Propagation of Hepatitis A Virus in Human Fibroblasts" Journal of Medical Virology 7(3) (1981) pp. 233-239.
Kojima et al. "Propagation of Human Hepatitis A Virus in Conventional Cell Lines" Journal of Medical Virology 7(4) pp. 273-286 (1981) Abstract only.
Flehmig, "Hepatitis A Virus in Cell Culture. II. Growth Characteristics of Hepatitis A Virus in Frhk-4/R Cells" Medical Microbiology and Immunology 170(2) (1981) pp. 73-81.
Aden et al, "Controlled Synthesis of HBsAg in a Differentiated Human Liver Carcinoma-Derived Cell Line" Nature 282 (12-1979) pp. 615-616.
Frosner et al, "Propagation of Human Hepatitis A Virus in a Hepatoma Cell Line" Abstracts of the Annual Meeting ASM (5-1980) abstract #S 57.
Siegl et al, "Propagation of Human Hepatitis A Virus in Hepatoma Cell Cultures" Experientia 30 (1980) p. 1448.
Frosner et al, "Propagation of Human Hepatitis A Virus in a Hepatoma Cell Line" Workshop of the Virology Section of the DGHM, Zentralblatt Fhur Bakteriologie, Parasitenkunde, Infekitionskrankheiten Und Hygine. vol. 248(1) (1980) pp. 15-16.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Production of hepatitis A virus in vitro utilizing a persistentl does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Production of hepatitis A virus in vitro utilizing a persistentl, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Production of hepatitis A virus in vitro utilizing a persistentl will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-1467892

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.