Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Patent
1994-06-10
1998-10-13
Stanton, Brian R.
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
435 696, 435 697, 4351723, 536 234, 536 235, 800 2, 935 34, C12N 1506, C12N 500, C07H 2104
Patent
active
058213511
ABSTRACT:
The present invention concerns a method and compositions of matter useful for the method of making, in transgenic animals, a human hemoglobin that is more stable and more readily purified from the endogenous hemoglobins of the transgenic animal than hemoglobin A. The hemoglobins produced by the invention include hemoglobin A.sub.2, which is an .beta..sub.2 .delta..sub.2 tetramer, as well as other hemoglobins having similar properties to hemoglobin A.sub.2 and have .beta./.delta.chimeric globins. The specification discloses a chimeric gene, encoding a human .delta.-globin that is expressed in transgenic animals at levels approximating the level of expression of the .alpha. or .beta. globin.
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Kumar Ramesh
Logan John S.
Sharma Ajay
Barrett Joseph B.
DNX Biotherapeutics
Stanton Brian R.
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