Production of gene and protein analogs through synthetic gene de

Details Production of gene and protein analogs through synthetic gene de Production of gene and protein analogs through synthetic gene de

1987-03-24

1989-12-19

Tieskin, Robin L.

Chemistry: molecular biology and microbiology

Treatment of micro-organisms or enzymes with electrical or...

Modification of viruses

435 694, 435320, 435 91, 935 9, 935 10, 935 11, 935 12, C12P 2100, C12P 2102, C12N 1500

Patent

active

048882860

ABSTRACT:
Methods and compositions are provided for the production of gene mutations and protein analogs using synthetic gene design and double-stranded synthetic oligonucleotide cassettes. The disclosure provides synthetic structural genes, synthetic double-stranded oligonucleotide cassettes and methods for the creation of synthetic gene analogs and polypeptide analogs by shortening or altering the native amino acid sequence.

REFERENCES:
patent: 4359535 (1982-11-01), Pieczenik
Guillemin et al., 1982, "Growth Hormone-Releasing Factor from a Human Pancreatic Tumor . . . ", Science, V. 218, 585-587.
Maniatis et al., 1982, Molecular Cloning A Laboratory Manual, Cold Spring Harbor Lab., pp. 11-14.
Rinderknecht et al., 1978, "The Amino Acid Sequence of Human Insulin-Like Growth Factor I . . . ", J. Biol. Chem. V. 282, pp. 2769-2776.
Delbadie-McFarland et al., Proc Natl. Acad. Sci., U.S.A., V. 79, pp. 6409-6413, Jun., 1982.
Wallace et al., Nucl. Acid Res., V. 9, No. 15, 1981.
Messing et al., Nucleic Acid Research, V. 9, No. 2, 1981, pp. 309-321.
Goeddel et al., Nature, V. 287, No. 5781, pp. 411-416, Oct., 1980.
Goeddel et al., Nucleic Acid Research, V. 8, No. 18, pp. 4057-4074.
Goeddel et al., Nature, V. 281, No. 5732, pp. 544-548, Oct., 1979.
The Peptides, Academic Press, 1983, Chapter 1, Synthesis of Polypeptides by Recombinant DNA Methods, Wetzel et al.
Itakura et al., Science, V. 198, pp. 1056-1063, Dec., 1977, and UK 2,007,676A.
Wetzel et al., Biochemistry, V. 19, pp. 6096-6104, 1980.
Crea et al., Nucl. Acids Research, V. 8, No. 10, 1980, pp. 2331-2348.
Itakura, Chemical Synthesis of Genes, Elsevier Biomedical Press, Dec., 1982, pp. 442-445.
Crea et al., Proc. Natl. Acad. Sci., U.S.A., V. 75, No. 12, pp. 5765-5769, Dec., 1978.
Smith et al., Nucl. Acids Res., V. 10, No. 15, 1982, pp. 4467-4482.
Scientific American, Feb., 1983, Synthetic Vaccines, pp. 66-74.
Atassi et al., Proc. Natl. Acad. Sci., U.S.A. No. 80, pp. 840-844, Feb., 1983.
Backman et al., "Construction of Plasmids Carrying the cI Gene of Bacteriophage .lambda.", 73 Proc. Natl. Acad. Sci. U.S.A. 11: 4174-4178 (1976).
Heffron et al., "In Vitro Mutagenesis of a Circular DNA Molecule by Using Synthetic Restriction Sites", 75 Proc. Natl. Acad. Sci. U.S.A. 12: 6012-6016.
Wilkinson et al., "A Large Increase in Enzyme-Substrate Affinity by Protein Engineering", Nature, 307: 187-188 (1984).
Stahl et al., "Replacement of the Bacillus subtillus Subtilisin Structural Gene . . . , "158 J. of Bacteriology, 2:411-418 (1984).
Tatchell et al., "In Vitro Mutation Analysis of the Mating-Type Locus in Yeast", Cell, 27: 25-35 (1981).
Sakonju et al., "A control Region in the Center of the 5S RNA Gene Directs Specific Initiation of Transcription: I. The 5' Border of the Region", Cell, 19:13-25 (1980).
Winter et al., "Redesigning Enzyme Structure by Site-Directed Mutagenesis: Tyrosyl tRNA Synthetase and ATP Binding", Nature, 299:756-758 (1982).

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