Production of .gamma.-linolenic acid by a .DELTA.6-desaturase

Chemistry: molecular biology and microbiology – Enzyme – proenzyme; compositions thereof; process for... – Oxidoreductase

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536 232, 435219, 435 691, 435183, 530350, C12N 950

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active

057892202

ABSTRACT:
Linoleic acid is converted into .gamma.-linolenic acid by the enzyme .DELTA.6-desaturase. The present invention is directed to isolated nucleic acids comprising the .DELTA.6-desaturase gene. More particularly, the isolated nucleic acid comprises the promoter, coding region and termination regions of the .DELTA.6-desaturase gene. The present invention provides recombinant constructions comprising the .DELTA.6-desaturase coding region in functional combination with heterologous regulatory sequences. The nucleic acids and recombinant constructions of the instant invention are useful in the production of GLA in transgenic organisms.

REFERENCES:
patent: 5614393 (1997-03-01), Thomas et al.
Griffiths et al. Delta-6 and Delta-12 Desaturase Activities and Phosphatidic Acid Formation in Microsomal Preparations from the Developing Cotyledons of Common Borage (Borago Officinalis). Biochemical Journal, vol. 252, pp. 641-647, 1988.
Stymne et al. Biosynthesis of Gamma-Linolenic Acid in Cotyledons and Microsomal Preparations of the Developing Seeds of Common Borage (Borago Officinalis). Biochemical Journal, vol. 240, pp. 385-393, 1986.
O. Sayonova et al. PNAS 94: 4211-6, Apr. 1997.

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