Production of dobutamine compounds

Details Production of dobutamine compounds Production of dobutamine compounds

1994-04-08

1995-08-15

Raymond, Richard L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Amino nitrogen containing

564374, 564381, C07C21300

Patent

active

054421209

ABSTRACT:
The invention relates to a process for the production of an acid addition salt of a dobutamine compound of the general formula ##STR1## wherein R is a hydrogen atom or a methyl group, and n is 1 or 2,
by reacting a mineral acid--addition salt of a dopamine compound of the general formula ##STR2## with a ketone of the general formula ##STR3## under the influence of a catalytic amount of a base, and in the presence of hydrogen and a hydrogenation catalyst, after which the pH of the reaction mixture is adjusted to approx. 6 at most and the product is isolated.

REFERENCES:
patent: 2276619 (1942-03-01), Kulz
patent: 4329367 (1982-05-01), Francis

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