Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Preparing oxygen-containing organic compound
Reexamination Certificate
2007-04-20
2010-11-02
Rao, Manjunath (Department: 1652)
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Preparing oxygen-containing organic compound
C435S257100, C426S417000, C426S601000, C426S648000
Reexamination Certificate
active
07824892
ABSTRACT:
Methods for production of highly unsaturated fatty acids by marine microorganisms, including the heterotrophic marine dinoflagellateCrypthecodinium, using low levels of chloride ion are disclosed. Specifically, methods of increasing production of highly unsaturated fatty acids by marine microorganisms while growing in low chloride media by manipulating sodium ion and potassium ion levels. The invention also relates to methods of production of highly unsaturated fatty acids by marine organisms at low pH levels, and includes methods for generation of low pH tolerant strains.
REFERENCES:
patent: 5130242 (1992-07-01), Barclay
patent: 5397591 (1995-03-01), Kyle et al.
patent: 5407957 (1995-04-01), Kyle et al.
patent: 5492938 (1996-02-01), Kyle et al.
patent: 5711983 (1998-01-01), Kyle et al.
patent: 6410281 (2002-06-01), Barclay
patent: 6566123 (2003-05-01), Barclay
patent: 7163811 (2007-01-01), Behrens et al.
patent: 7252979 (2007-08-01), Behrens et al.
patent: 2001/0016342 (2001-08-01), Higashiyama et al.
patent: 2008/0032352 (2008-02-01), Behrens et al.
patent: 2008/0032353 (2008-02-01), Behrens et al.
patent: 2008/0032354 (2008-02-01), Behrens et al.
patent: 2008/0032355 (2008-02-01), Behrens et al.
patent: 2008/0032356 (2008-02-01), Behrens et al.
patent: 2008/0032358 (2008-02-01), Behrens et al.
patent: 2008/0032359 (2008-02-01), Behrens et al.
patent: 2008/0044865 (2008-02-01), Behrens et al.
patent: 2008/0044866 (2008-02-01), Behrens et al.
patent: 2008/0166780 (2008-07-01), Barclay
patent: 07-075556 (1995-03-01), None
patent: 2000-60587 (2000-02-01), None
patent: WO 98/29558 (1998-07-01), None
patent: WO 01/53512 (2001-07-01), None
patent: WO 01/76385 (2001-10-01), None
patent: WO 01/76715 (2001-10-01), None
patent: WO 2005/035775 (2005-04-01), None
Aqua Craft.RTM., Inc., Issue No. 3, The Facts About Instant Ocean.RTM., http://www.aquacraft.net/w0014. html, .COPYRGT. 2000, printed on Jan. 6, 2006.
Beach et al.; Environmental Influences on the Docosahexaenoate Content of the Triacylglycerols and Phosphatidylcholine of a Heterotrophic, Maine Dinoflagellate.Crypthecodinium cohnii; Biochimica et Biophysica Aeta; (1973); 316:56-65.
de Swaaf ME, et al., Analysis of docosahexaenoic acid biosynthesis inCrypthecodinium cohniiby 13C labelling and desaturase inhibitor experiments, J Biotechnol. Jun. 12, 2003;103(1):21-9.
de Swaaf ME, et al., Fed-batch cultivation of the docosahexaenoic-acid-producing marine algaCrypthecodinium cohniion ethanol, Appl Microbiol Biotechnol. Mar. 2003;61(1):40-3. Epub Dec. 24, 2002.
De Swaaf ME, et al., High-cell-density fed-batch cultivation of the docosahexaenoic acid producing marine algaCrypthecodinium cohnii, Biotechnol Bioeng. Mar. 20, 2003;81(6):666-72.
de Swaaf ME, et al., Optimisation of docosahexaenoic acid production in batch cultivations byCrypthecodinium cohniiJ Biotechnol. 1999 70:185-92.
Home; “Marine Chemistry Chapter 5: Elemental Composition of the Seas and Salinity Variations”; Wiley-Interscience; (1969); pp. 151-155.
Jiang et al.; “Effects of Salinity on Cell Growth and Docosahexaenoic acid content of the Heterotrophic Marine MicroalgaCrypthecodinium cohnii,” J Industrial Microbiol & Biotechnol; (1999); 23(6):508-513.
Jiang et al.; Effects of Medium Glucose Concentration and pH on Docosahexaenoic Acid Content of HeterotrphicCrypthecodinium cohnii; Process Biochemistry ; (2000); 35:1205-1209.
Sijtsma L and de Swaaf ME, Biotechnological production and applications of the omega-3 polyunsaturated fatty acid docosahexaenoic acid, Appl Microbiol Biotechnol. Apr. 2004;64(2):146-53. Epub Jan. 22, 2004.
Stein; “Handbook of Phycological Methods” Cambridge University Press; (1973):33.
Tuttle et al.; An Optimal Growth Medium for the DinoflagellateCrypthecodinium cohnii; Phycologia; (1975): vol. 14(1):1-8.
Vazhappilly et al.; “Eicosapentaenoic Acid and Docosahexaenoic Acid Production Potential of Microalgae and Their Heterotrophic Growth”; Journal of the American Oil Chemists Society, (1998) vol. 75, No. 3 p. 393-397.
International Search Report for International (PCT) Patent Application No. PCT/US04/32383, mailed Jan. 31, 2005.
Written Opinion for International (PCT) Patent Application No. PCT/US04/32383, mailed Jan. 31, 2005.
International Preliminary Report on Patentability for International (PCT) Patent Application No. PCT/US04/32383, issued Apr. 3, 2006.
Barrette et al., “Development of bacterial contamination during production of yeast extracts,” Applied and Environmental Microbiology 65(7):3261-3263, 1999.
Fermentation Process Development of Industrial Organisms, Neway, ed., Marcel Dekker/CRC Press, Boca Raton, 1989, pp. 244-246.
Wang, J., et al., “Effects of Environmental Conditions on Growth and DHA Yield ofCrypthecodinium cohnii,” Marine Sciences26(2):62-65, China Academic Journal Electronic Publishing House, CN (2000), Abstract only.
English language translation of Wang, J., et al., “Effects of Environmental Conditions on Growth and DHA Yield ofCrypthecodinium cohnii,” (2000) (Document NPL1).
English language translation of the Notice of Reasons for Rejection for Japanese Patent Appl. No. 2006-534148, mailed Mar. 29, 2010.
BD Bionutrients Technical Manual, 3d ed., http://www.bd.com/ds/technicalCenter/index.asp, 2006, 4 pages.
Apt Kirk
Behrens Paul W.
Fichtali Jaouad
Hansen Jon
Lippmeier James Casey
Kosson Rosanne
Martek Biosciences Corporation
Rao Manjunath
Sterne Kessler Goldstein & Fox P.L.L.C.
LandOfFree
Production of DHA in microalgae in medium having modified... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Production of DHA in microalgae in medium having modified..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Production of DHA in microalgae in medium having modified... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-4166457