Production of coformycin and intermediates therefor

Details Production of coformycin and intermediates therefor Production of coformycin and intermediates therefor

1974-10-24

1976-05-25

Brown, Johnnie R.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

204158R, 424180, C07H 1918

Patent

active

039592570

ABSTRACT:
This invention relates to a process for the preparation of coformycin, 3-(.beta.-D-ribofuranosyl)-6,7,8-trihydroimidazo[4,5-d][1,3]diazepin-8(R)- ol, through a synthetic route from a new derivative of 9-.beta.-D-ribofuranosyl-purine and other synthetic intermediates involved in the process and their preparation.

REFERENCES:
patent: 3535207 (1970-10-01), Shiro et al.
Hudson, "Advances In Carbohydrate Chemistry", Vol. 8, 1953, Academic Press Inc. New York, N.Y., pp. 112-115.
Sawa et al. "Jour. Antibotics, Ser. A." Vol. 20, No. 4, pp. 227-231, July, 1967.
Ohno et al. "Jour. Amer. Chem. Soc." Vol. 96, No. 13, pp. 4326-4327, June, 1974.
Nakamura et al. "Jour. Amer. Chem. Soc." Vol. 96, No. 13, pp. 4327-4328, June, 1974.

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