Production of chimeric mouse-human antibodies with specificity t

Details Production of chimeric mouse-human antibodies with specificity t Production of chimeric mouse-human antibodies with specificity t

1994-12-27

1996-11-19

Saunders, David

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

435 696, 4351723, 5303873, 530808, G07K 1630, G01N 33574

Patent

active

055761844

ABSTRACT:
Gene expression elements and their use in production of chimeric antibodies with human constant regions and murine variable regions, and mouse human chimeric antibodies having specificity to human tumor cells, methods of their production, and their use.

REFERENCES:
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Whittle, Nigel et al., "Expression in COS Cells of a Mouse-Human Chimaeric B72.3 Antibody, " Protein Engineering 1:499-505, Dec. 1987.
R. O. Dillman, Ann. Intern. Med., III, 592-603, 1989.
W. J. Harris et al, Trends in Biotechnology, II, 42-44, 1993.
V. Hird et al, in D. Carney et al. (EDS.), Genes and Cancer, John Wiley & Sons Ltd., 1990, pp. 183-189.
E. J. Wawrznczak et al, Clin. Exp. Immunol., 82, 189-193, 1990.
Nose et al, Proc. Natl. Acad. Sci, USA, 80, 6632, 1983.
European Search Report of 0 364 096.
Nishimura et al, Cancer Res., 47, 999-1005, 1987.

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