Production of chimeric antibodies by homologous recombination

Details Production of chimeric antibodies by homologous recombination Production of chimeric antibodies by homologous recombination

1993-04-12

1996-01-09

Chambers, Jasemine C.

Chemistry: molecular biology and microbiology

Vector, per se

4351723, 435 691, 435 696, 935 15, 935 70, 5303873, 5303888, C12N 1500, C12N 500

Patent

active

054828562

ABSTRACT:
A process for producing chimeric antibodies using novel recombinant DNA vectors and homologous recombination in vivo is described. The recombinant DNA constructs of the invention can be used to transfect antibody producing cells so that targeted homologous recombination occurs in the transfected cells leading to gene modification and the production of chimeric antibody molecules by the transfected cells.

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