Production of chimeric antibodies by homologous recombination

Details Production of chimeric antibodies by homologous recombination Production of chimeric antibodies by homologous recombination

1990-01-22

1993-04-13

Chambers, Jasemine C.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

435 697, 435 7021, 4351723, 435 701, 4353201, 935 15, 935111, 5303873, 5303888, 536 2353, C12P 2100, C12N 1500

Patent

active

052022382

ABSTRACT:
A process for producing chimeric antibodies using novel recombinant DNA vectors and homologous recombination in vivo is described. The recombinant DNA constructs of the invention can be used to transfect antibody producing cells so that targeted homologous recombination occurs in the transfected cells leading to gene modification and the production of chimeric antibody molecules by the transfected cells.

REFERENCES:
Morrison, Science 229 1202-1207 (1985).
Smithies et al., Nature 317:230-234 (1985).
Hellstrom et al., Cancer Res. 46:3917-3923.
Doetschman et al., Nature 330:576-578 (1987).
Hohmann et al., 1987, Curr. Genet. 12:519-526.
Folger et al., 1985, Mol. Cell. Biol. 5:59-69.
Lin et al., 1985, Proc. Natl. Acad. Sci. U.S.A. 82:1391-1395.
Roth and Wilson, 1985, Proc. Natl. Acad. Sci. U.S.A. 82:3355-3359.
Shaul et al., 1985, Proc. Natl. Acad. Sci. U.S.A. 82:3781-3784.
Anderson et al., 1984, Proc. Natl. Acad. Sci. U.S.A. 81:206-210.
Bandyopadhyay et al., 1984, Proc. Natl. Acad. Sci. U.S.A. 81:3476-3480.
Folger et al., 1984, Cold Spring Harbor Symp. Quant. Biol. 49:123-138.
Katinka, 1984, Biochimie 66:681-692.
Kucherlapati et al., 1984, Proc. Natl. Acad. Sci. U.S.A. 81:3153-3157.
Lin et al., 1984, Mol. Cell. Biol. 4:1020-1034.
Goodenow et al., 1983, Nature 301:388-394.
Subramani and Berg, 1983, Mol. Cell. Biol. 3:1040-1052.
Folger et al., 1982, Mod. Cell. Biol. 2:1372-1387.
Morrison et al., 1984, Proc. Natl. Acad. Sci. U.S.A. 81:6851-6855.
Robins et al., 1981, Cell. 23:29-39.

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