Production of chemical compounds with immoblized plant cells

Details Production of chemical compounds with immoblized plant cells Production of chemical compounds with immoblized plant cells

1984-06-20

1986-03-25

Naff, David M.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

435 52, 435 68, 435178, 435180, 435182, 435240, C12P 100, C12P 3300, C12P 2100, C12N 1104

Patent

active

045783519

ABSTRACT:
Plant cells containing intra-cellular chemical compounds are induced to excrete the compounds by maintaining the cells in a sufficiently high cell density. A sufficiently high cell density is preferably maintained by immobilizing the cells in a modified polyacrylamide gel containing polyacrylamide and a minor amount of xanthan gum or sodium alginate. Vinca plant cells can be immobilized to produce the chemical compounds, ajmalicine and serpentine. Alternative to immobilizing the cells, a sufficiently high cell density can be provided by maintaining the cells in a permeable enclosure such as a woven nylon bag.

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Morikama et al., Biotechnology and Bioengineering, vol. XXI, 1979, pp. 261-270.
Karube et al., Biotechnology and Bioengineering, vol. XXI, 1979, pp. 253-260.

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