Production of cephalosporins

Details Production of cephalosporins Production of cephalosporins

1979-04-25

1983-01-11

Tanenholtz, Alvin E.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing compound having a 1-thia-5-aza-bicyclo

435 48, 435 49, 435172, 435254, 435911, C12P 3500

Patent

active

043682634

ABSTRACT:
An improved strain of Acremonium chrysogenum may be produced by submitting parent strains of Acremonium chrysogenum to protoplast fusion and nuclear fusion and selecting said improved strain from the progeny or from a mutant thereof.
The improved strains have operational advantages for the production of cephalosporins compared with the parental strains.
The invention also relates to a method of producing a cephalosporin by culturing the improved strain of Acremonium chrysogenum.

REFERENCES:
patent: 3929577 (1975-12-01), Kanzaki et al.
Anne' et al., Journal of General Microbiology 92, 413-417 (1976).
Nuesch et al., Genetics of Industrial Microorganisms vol. II, pp. 317-321 (1973).
Esser, Endeavour vol. 1, No. 3/4.148 pp. 143-148 (1977).

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