Production of blood coagulation factor VIII:C

Details Production of blood coagulation factor VIII:C Production of blood coagulation factor VIII:C

1982-06-28

1983-08-09

Rosen, Sam

Drug, bio-affecting and body treating compositions

Fermentate of unknown chemical structure

Having a known elemental analysis

A61K 3514

Patent

active

043978410

ABSTRACT:
A concentrate of blood coagulation Factor VIII:C is obtained in high yield by fractionation of blood plasma with a sequence of adsorption steps employing two different water-insoluble, cross-linked polyelectrolyte copolymers, each in the presence of exogenous heparin.

REFERENCES:
patent: Re29698 (1978-07-01), Fekete et al.
patent: 3555001 (1971-01-01), Wallis et al.
patent: 4157431 (1979-06-01), Fields et al.
patent: 4203891 (1980-05-01), Rock
patent: 4278594 (1981-07-01), Amrani
patent: 4289691 (1981-09-01), Rock et al.
patent: 4348315 (1982-09-01), Blomback
patent: 4361509 (1982-11-01), Zimmerman
A. J. Johnson et al., J. Lab. Clin. Med. 92(a), 194-210 (1978).
A. J. Johnson et al., Thromb. Diath. Haemorrh. 34, N2, 589 (1975).

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