Production of .beta.-form thiamine hydrochloride crystals

Details Production of .beta.-form thiamine hydrochloride crystals Production of .beta.-form thiamine hydrochloride crystals

1992-09-15

1994-03-01

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Particulate form

514951, 514952, A61K 914, A61K 3151

Patent

active

052905683

ABSTRACT:
A method of producing .beta.-form thiamine hydrochloride crystals which comprises moistening .alpha.-form thiamine hydrochloride crystals in the presence of .beta.-form thiamine hydrochloride crystals as seed crystals and stirring the mixture and a method of producing pharmaceutical preparations containing .beta.-form thiamine hydrochloride crystals which comprises moistening .alpha.-form thiamine hydrochloride crystals, together with a binder, with water in the presence of .beta.-form thiamine hydrochloride crystals as seed crystals and stirring the mixture.
.beta.-Form thiamine hydrochloride crystals which are stable and resistant to caking and pharmaceutical preparations containing the same can be produced in a simple and easy manner.

REFERENCES:
patent: 4702919 (1987-10-01), Kitamori et al.

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