Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...
Patent
1999-04-12
2000-08-08
Davis, Zinna Northington
Organic compounds -- part of the class 532-570 series
Organic compounds
Heterocyclic carbon compounds containing a hetero ring...
546340, C07D41700
Patent
active
061004030
ABSTRACT:
A method of producing a compound represented by the formula: ##STR1## wherein R.sup.1 stands for hydrogen or an optionally substituted alkyl or acyl group, which comprises reacting a compound represented by the formula: ##STR2## wherein R.sup.1 is of the same meaning as defined above, and R.sup.2 stands for an optionally halolgenated alkyl group or an optionally substituted phenyl group with a compound represented by the formula: ##STR3## in a lower alcohol in the presence of an alkali metal or alkaline earth metal carbonate; the compound (III) being useful as starting compounds for producing thiazolidinedione derivatives having hypoglycemic and hypolipidemic activities.
REFERENCES:
Y. Momose et al. "Studies on Antidiabetic Agents. X..sup.1) Synthesis and Biological Activities of Pioglitazone and Related Compounds", Chem. Pharm. Bull., vol. 39, No. 6, pp. 1440-1445, 1991.
Mizufune Hideya
Saito Yuzuru
Yamashita Makoto
Davis Zinna Northington
Takeda Chemical Industries Ltd.
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