Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Reexamination Certificate
2005-01-04
2005-01-04
Chan, Christina (Department: 1644)
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
C435S069600, C435S069700, C435S070100, C435S254100, C424S130100, C424S134100
Reexamination Certificate
active
06838254
ABSTRACT:
A process is provided for the production of an antibody or a fragment or functionalized fragment thereof using a transformed lower eukaryotic host containing an expressible DNA sequence encoding the antibody or (functionalized) fragment thereof, wherein the antibody or (functionalized) fragment thereof is derived from a heavy chain immunoglobulin ofCamelidaeand is devoid of light chains, and wherein the lower eukaryotic host is a mould, preferably belonging to the generaAspergillusorTrichoderma,or a yeast, preferably belonging to the yeast generaSaccharomyces, Kluyveromyces, Hansenula, or Pichia. The heavy chain fragment can contain at least the whole variable domain. A complementary determining region (CDR) different from the CDR belonging to the natural antibody exCamelidaecan be grafted on the framework of the variable domain of the heavy chain immunoglobulin. The catalytic antibodies can be raised inCamelidaeagainst transition state molecules. The functionalized antibody or fragment thereof can comprise a fusion protein of both heavy chain immunoglobulin fromCamelidaeor a fragment thereof and another polypeptide, e.g., an enzyme, preferably an oxido-reductase. Also provided are new products obtainable by a process as described, and compositions containing a product produced by a process as described, which composition may contain a new product as provided.
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Frenken Leon G. J
Hamers Raymond
Hamers-Casterman Cecile
Muyldermans Serge V.M
Verrips Cornelis T
Chan Christina
Conopco Inc.
DiBrino Marianne
Morgan & Lewis & Bockius, LLP
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