Production of antibodies from transgenic animals

Details Production of antibodies from transgenic animals Production of antibodies from transgenic animals

1994-08-05

1996-08-13

Ziska, Suzanne E.

Multicellular living organisms and unmodified parts thereof and

Nonhuman animal

4241841, 5303873, 53038815, 5303871, 4351723, 4351722, 536 2353, C12N 1500, A61K 3900, C07K 1600, C12P 2108

Patent

active

055458076

ABSTRACT:
Chimaeric or wholly foreign immunoglobulin is obtained from cells or body fluid of a transgenic animal which has had inserted into its germline genetic material that encodes for at least part of an immunoglobulin, of foreign origin or that can rearrange to encode a repertoire of immunoglobulins, i.e. derived from a different animal source. For example, wholly human immunoglobulins may be produced from a transgenic mouse, possibly in response to an immunogen subsequently introduced to the mouse.

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Alt et al. TIG 1:1, 1985 (Aug.).
Berma et al. EMBO J 7(3): 727 198.
Goodhardt et al PNAS 84, 4229, 1987.
Ritchie et al Nature 312: 517 1984.
Goodnow et al Nature 334: 676, 1988.
Bruggeman et al J. Exp. Med. 166: 1351, 1907.
Scangos et al T1G 24: 285, 1987.
Bucchini et al, "Rearrangement of a chicken immunoglobulin gene occurs in the lymphoid lineage of mice", Nature, vol. 326, Mar. 1987, pp. 409-411.
Bruggemann et al, "A repertoire of monoclonal antibodies with human heavy chains from transgenic mice", Proc. Natl. Acad. Sci. USA, vol. 86, Sep. 1989, pp. 6709-6713.

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