Production of antibiotics neothramycin A and neothramycin B

Details Production of antibiotics neothramycin A and neothramycin B Production of antibiotics neothramycin A and neothramycin B

1976-12-06

1977-09-20

Jones, Raymond N.

Textiles: fiber preparation

2602393T, 2603265B, C12D 139/14

Patent

active

040494977

ABSTRACT:
There are disclosed two new antibiotics formerly denominated MC916-A and MC916-B and now called neothramycin A and neothramycin B which are potent inhibitors of the growth of leukemia cells, e.g. Leukema L-1210 cells in mice. They are produced by controlled fermentation of Streptomyces FERM-P 2452 (A.T.C.C. 31123).

REFERENCES:
patent: 3074855 (1963-01-01), Okuda et al.
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Zaretskii et al., "Effect of some Anticancer Antibiotics on mouse leukemia," Chemical Abstracts, vol. 56, (May), Abs. No. 12276e.
Shirling et al., "Cooperative Description of Type Strains of Streptomyces," International Journal of Systematic Bacteriology, vol. 22, No. 4, p. 323 (1972).
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Shirling et al., "Cooperative Description of Type Cultures of Streptomyces Species Descriptions from First Study," International Journal of Systematic Bacteriology, vol. 18, (1968), p. 122.
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