Production of amino acids and amino acid derivatives bearing iso

Organic compounds -- part of the class 532-570 series – Organic compounds – Carboxylic acids and salts thereof

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560 37, 560 39, 560154, 560169, 560171, 562443, 562444, 562557, 562561, 562562, 562571, C07C22900

Patent

active

052547302

ABSTRACT:
Amino acids and amino acid derivatives bearing isotopic hydrogen labels at both the .alpha.- and .beta.-positions are produced when N-substituted azomethine derivatives of carboxylic acids and carboxylic acid derivatives are hydrogenated over metal catalysts in isotopically-enriched protic solvents with molecular hydrogen.

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patent: 3976689 (1976-08-01), Reinhold
Lemaster, D. J. Labelled Compounds and Radiopharmaceuticals, 1982 vol. 19, 639-46.
Stein, R. Analytical Biochemistry, 1981, vol. 116, 230-6.
Rittenberg, D. J. Amer. Chem. Soc., 1940, vol. 62, 2249-50.
Kilgore, J. L. J. Chem. Soc., Perkin. Trans. I, 1991, 79-84.

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