Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Reexamination Certificate
2006-02-21
2006-02-21
Weber, Jon (Department: 1653)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
C435S069100, C435S069700, C435S007930, C435S174000, C530S350000, C530S412000, C536S023100, C536S023400, C536S023500, C930S010000
Reexamination Certificate
active
07001729
ABSTRACT:
Compositions and methods are provided for producing adenine nucleotide translocator (ANT) polypeptides and fusion proteins, including the production and use of recombinant expression constructs having a regulated promoter. ANT ligands and compositions and methods for identifying ANT ligands, agents that bind ANT and agents that interact with ANT are also disclosed.
REFERENCES:
patent: 0 130 074 (1985-01-01), None
patent: 0 477 961 (1992-04-01), None
patent: 0 770 610 (1997-05-01), None
patent: WO 98/19714 (1998-05-01), None
patent: WO 98/28415 (1998-07-01), None
patent: WO 99/07845 (1999-02-01), None
Hatanaka et al. Significant Expression of Functional Human Type 1 Mitochondrial ADP/ATP Carrier in Yeast Mitochondria. (2001) Biol. Pharm. Bull. 24(6) 595-599.
Heimpel et al. Expression of Mitochondrial ADP/ATP Carrier inEscherichia coli. (2001) J. Biol. Chem. 276(15): 11499-11506.
Miroux et al. Over-production of Proteins inEscherichia coli: Mutant Hosts that Allow Synthesis of some Membrane Proteins and Globular Proteins at High Levels. (1996) J. Mol. Biol. 260: 289-298.
Fiermonte et al. Abundant bacterial expression and reconstitution of an intrinsic membrane-transport protein from bovine mitochondria. (1993) Biochem. J. 294: 293-299.
Neumann et al. Induction of Multiple Heart Autoantibodies in Mice with Coxsackievirus B3- and Cardiac Myosin-Induced Autoimmune Myocarditis. J. Immunol. (1994) 152: 343-350.
Adrian et al., “Sequences Required for Delivery and Localization of the ADP/ATP Translocator to the Mitochondrial Inner Membrane,”Molecular and Cellular Biology 6(2):626-634, 1986.
Aquila et al., “Complete Amino Acid Sequence of the ADP/ATP Carrier from Beef Heart Mitochondria,”Hoppe-Seyler's Z. Physiol. Chem. 363:345-349, 1982.
Block et al., “Atractyloside and Bongkrekic Acid Sites in the Mitochondrial ADP/ATP Carrier Protein,”FEBS Letters 131(2):213-218, 1981.
Block et al., “Chemical Modifications and Active Site Labeling of the Mitochondrial ADP/ATP Carrier,”Methods in Enzymology 125:658-670, 1986.
Block et al., “Fluorescent Probes of the Mitochondrial ADP/ATP Carrier Protein,”Methods in Enzymology 125: 639-649, 1986.
Bojanovski et al., “Studies on the Adenine Nucleotide Translocase from Rat Liver Mitochondria,”Eur. J. Biochem.71:539-548, 1976.
Boulay et al., “Photolabeling Approach to the Study of the Topography of the Atractyloside Binding Site in Mitochondrial Adenosine 5′-Diphosphate/Adenosine 5′-Triphosphate Carrier Protein,”Biochemistry 22: 477-484, 1983.
Boulay et al., “Synthesis and Properties of Fluorescent Derivatives of Atractyloside as Potential Probes on the Mitochondrial ADP/ATP Carrier Protein,”Analytical Biochemistry 128:323-330, 1983.
Brandolin et al, “Partial Purification of an Atractyloside-Binding Protein from Mitochondria,”FEBS Letters 46(1):149-153, 1974.
Brandolin et al., “Substrate-Induced Modifications of the Intrinsic Fluorescence of the Isolated Adenine Nucleotide Carrier Protein: Demonstration of Distinct Conformational States,”Biochemistry 24:1991-1997, 1985.
Brunelli and Pall, “A Series of Yeast Shuttle Vectors for Expression of cDNAs and Other DNA Sequences,”Yeast 9:1299-1309, 1993.
Cozens et al., “DNA Sequences of Two Expressed Nuclear Genes for Human Mitochondrial ADP/ATP Translocase,”J. Mol. Biol. 206:261-280, 1989.
Fiore et al., “The Mitochondrial ADP/ATP Carrier: Structural, Physiological and Pathological Aspects,”Biochimie 80:137-150, 1998.
Giraud et al., “Expression of HumanANT2Gene in Highly Proliferative Cells: GRBOX, a New Transcriptional Element, Is Involved in the Regulation of Glycolytic ATP Import into Mitochondria,”J. Mol. Biol. 281:409-418, 1998.
Green and Reed, “Mitochondria and Apoptosis,”Science 281:1309-1312, Aug. 28, 1998.
Klingenberg et al., “Isolation of the ADP, ATP Carrier as the Carboxyatractylate Protein Complex from Mitochondria,”Biochimica et Biophysica Acta 503:193-210, 1978.
Klingenberg, “The ADP-ATP Translocation in Mitochondria, a Membrane Potential Controlled Transport,”J. Membrane Biol. 56:97-105, 1980.
Klingenberg, M., “Principles of Carrier Catalysis Elucidated by Comparing Two Similar Membrane Translocators from Mitochondria, the ADP/ATP Carrier and the Uncoupling Protein,”Annals New York Academy of Sciences 456:279-288, 1985.
Ku et al., “The Human Fibroblast Adenine Nucleotide Translocator Gene,”Journal of Biological Chemistry 265(27): 16060-16063, 1990.
Lauquin and Vignais, “Interaction of [3H]Bongkrekic Acid with the Mitochondrial Adenine Nucleotide Translocator,”Biochemistry 15(11):2316-2322, 1976.
Lauquin et al., “Isobongkrekic Acid, a New Inhibitor of Mitochondrial ADP-ATP Transport: Radioactive Labeling and Chemical and Biological Properties,”Biochemistry 15(11):2323-2327, 1976.
Li et al., “A Human Muscle Adenine Nucleotide Translocator Gene Has Four Exons, is Located on Chromosome 4, and is Differentially Expressed,”Journal of Biological Chemistry 264(24): 13998-14004, 1989.
Li et al., “OXBOX, a Positive Transcriptional Element of the Heart-Skeletal Muscle ADP/ATP Translocator Gene,”Journal of Biological Chemistry 265(33): 20585-20588, 1990.
Marzo et al., “Bax and Adenine Nucleotide Translocator Cooperate in the Mitochondrial Control of Apoptosis,”Science 281:2027-2031, Sep. 25, 1998.
Murdock et al., “Up-Regulation of Nuclear and Mitochondrial Genes in the Skeletal Muscle of Mice Lacking the Heart/Muscle Isoform of the Adenine Nucleotide Translocator,”The Journal of Biological Chemistry 274(20):14429-14433, May 14, 1999.
Piozzi et al., “Structure of Atroctyloside,” Chemical Abstracts Acc. No. 67:117201, 1967.
Piozzi et al., “Struttura dell'attrattiloside,”Gazetta Chimica Italiana 97(6): 935-954, 1967. (English summary on p. 936).
Plano et al., “Rickettsia Prowazekii and ATP/ADP Translocase,”Annals of the New York Academy of Sciences 590: 397-407, 1990.
Rosenberg,Protein Analysis and Purification: Benchtop Techniques,Birkhauser, Boston, pp. 335-347, 1996.
Roux et al., “Fluorometric Titration of the Mitochondrial ADP/ATP Carrier Protein in Muscle Homogenate with Atractyloside Derivatives,”Analytical Biochemistry 234:31-37, 1996.
Santi and Luciani (eds.),Atractyloside: Chemistry, Biochemistry and Toxicology,Piccin Medical Books, Padova, Italy, 1978.
Smagula and Douglas, “Mitochondrial Import of the ADP/ADP Carrier Protein inSaccharomyces cerevisiae,” Journal of Biological Chemistry 263(14): 6783-6790, 1988.
Sterling, “Direct Thyroid Hormone Activation of Mitochondria: The Role of Adenine Nucleotide Translocase,”Endocrinology 119(1):292-295, 1986.
Stubbs, “Inhibitors of the Adenine Nucleotide Translocase,”Pharmac. Ther. 7:329-349, 1979.
Tjaden et al. “Expression of a Plastidic ATP/ADP Transporter Gene inEscherichia coliLeads to a Functional Adenine Nucleotide Transport System in the Bacterial Cytoplasmic Membrane,”Journal of Biological Chemistry 273(16): 9630-9636, 1998.
Vignais et al., “[60]3H- or35S-Labeled Atractyloside and Carboxyatractyloside, Atractyloside Derivatives Used for Affinity Chromatography, Photoaffinity Labeling, and Spin Labeling, and3H- or14C-Labeled Bongkrekic Acid,”Methods in Enzymology 55:518-533, 1979.
Vignais et al., “Adenosine Diphospahte Translocation in Mitochondria. Nature of the Receptor Site for Carboxyatractyloside (Gummiferin),”Biochemistry 12(8): 1508-1519, 1973.
Yan and Sohal, “Mitochondrial Adenine Nucleotide Translocase is Modified Oxidatively During Aging,”Proc. Natl. Acad. Sci. USA 95:12896-12901, Oct. 1998.
Anderson Christen M.
Clevenger William
Davis Robert E.
Ghosh Soumitra S.
Miller Scott W.
Migenix Corp.
Schnizer Holly
Seed IP Law Group PLLC
Weber Jon
LandOfFree
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