Production of acyl phosphate salts

Details Production of acyl phosphate salts Production of acyl phosphate salts

1976-03-15

1978-05-09

Morgenstern, Norman

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

260545P, 260558R, 260 56R, 536 27, C07C 5156, C07C 8706, C07F 906

Patent

active

040886751

ABSTRACT:
Acyl phosphate salts suitable for use as phosphate donors in the production of cofactors, such as adenosine triphosphate, are prepared by acylation of phosphoric acid with a ketene, followed by reaction with ammonia or an amine. The reaction product, e.g. diammonium acetyl phosphate, can normally be used directly in enzymic production of cofactors without the necessity of prior conversion to the free acid or another salt, such as the sodium salt. The acyl phosphate salts are produced in high yields, and the method allows production of cofactors for use in biosynthesis from readily available materials.

REFERENCES:
patent: 3387024 (1968-06-01), Quimby
patent: 3400147 (1968-09-01), Rogovin et al.
patent: 3422137 (1969-01-01), Quimby
patent: 3496223 (1970-02-01), Irani et al.
Whitesides et al., "J. Org. Chem.", 40:2516 (1975).
Bently, "J.A.C.S." 70:2183 (1948).
Kasalopoff et al., "Org. Phos. Comp." vol. 6, pp. 294-296 (1975).

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