Production of acetaminophen

Details Production of acetaminophen Production of acetaminophen

1988-07-12

1990-09-04

Kight, III, John

Organic compounds -- part of the class 532-570 series

Organic compounds

Amino nitrogen containing

564305, C07C23105, C07C23342, C07C23512, C07C23516

Patent

active

049546520

ABSTRACT:
N-acetyl-para-aminophenol is prepared by subjecting 4-hydroxyacetophenone oxime to a Beckmann rearrangement in the presence of a thionyl chloride catalyst and an alkyl alkanoate as the reaction solvent. An integrated process is disclosed wherein 4-hydroxyacetophenone is reacted with a hydroxyl amine salt and a base to obtain the ketoxime of the ketone, e.g., 4-hydroxyacetophenone oxime, extracting the ketoxime product from the reaction with alkanoate ester and subjecting the ketoxime dissolved in the ester to a Beckmann rearrangement in the presence of a thionyl chloride catalyst.

REFERENCES:
patent: 4524217 (1985-06-01), Davenport et al.
patent: 4560789 (1985-12-01), Davenport et al.
patent: 4568763 (1986-02-01), Davenport et al.

Affiliated with

Also associated with

Rating

Production of acetaminophen does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Production of acetaminophen, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Production of acetaminophen will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-443439