Production of a new hirudin analog and anticoagulant pharmaceuti

Details Production of a new hirudin analog and anticoagulant pharmaceuti Production of a new hirudin analog and anticoagulant pharmaceuti

1992-07-08

1996-05-14

Walsh, Stephen G.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

435 691, 435 697, 43525233, 4353201, 530324, 536 234, 536 235, 514 12, 930250, C07K 710, A61K 3764, C12N 1515, C12N 1570

Patent

active

055166563

ABSTRACT:
Provided is a chimeric HV1/HV3 hirudin analog useful as an anti-coagulant, exhibiting higher anti-thrombin activity and less tendency to cause bleeding than hirudin HV1. Also provided are a method of producing hirudins and hirudin analogs, as well as other proteins, employing secretion vectors, and transformed microorganisms such as E. coli. Pharmaceutical compositions comprising various hirudins or the chimeric HV1/HV3 hirudin analog of the present invention and a pharmaceutically acceptable carrier are also disclosed.

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Braun et al., (1988) Biochemistry 27:6517-6522.
Dodt et al., "Expression, secretion and processing of hirudin in E. coli . . . ", FEBS Lett. 202(3): 373-377, Jun. 1986.
Riehl-Bellon et al, "Purification and Biochemical Characterization of Recombinant Hirudin . . . ", Biochem. 28:2941-2949, Apr. 1989.
Mao et al, "Interaction of Hirudin with Thrombin . . . " Biochem. 27:8170-8173, Oct. 1988.
Schulz et al, "Principles Of Protein Structure", pp. 14-16, 1979.

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