Production of a multimeric protein by cell fusion method

Details Production of a multimeric protein by cell fusion method Production of a multimeric protein by cell fusion method

2003-11-20

2008-09-30

Helms, Larry R. (Department: 1643)

Drug, bio-affecting and body treating compositions

Immunoglobulin, antiserum, antibody, or antibody fragment,...

Structurally-modified antibody, immunoglobulin, or fragment...

C424S142100

Reexamination Certificate

active

07429380

ABSTRACT:
The present invention features a method of producing a multimeric protein from a hybrid cell formed from the fusion of two or more cells, each of which cell is engineered to express one component of the multimeric protein, as well as a method for screening for successful fusion of the cells to produce a desired hybrid cell. The methods of the invention are widely applicable to the production of proteins having two or more components.

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