Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Preparing compound having a 1-thia-5-aza-bicyclo
Patent
1994-11-02
1997-04-08
Marx, Irene
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Preparing compound having a 1-thia-5-aza-bicyclo
435227, 435197, C12P 3500, C12N 979
Patent
active
056186878
ABSTRACT:
An enzymatic process for the production of 7-amino cephalosporanic acid from cephalosporine C is disclosed. The process is a two-stage enzymatic reaction which can be performed in a single reactor. The invention further includes a mutant strain of Trigonopsis variabilis which produces increased amounts of D-amino acid oxidase, and a mutant strain of Acinetobacter sp., which increased amounts of deacylase, which are enzymes necessary for the present process.
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Berg and Rodden, Analytical Biochemistry 71:214-222 (1976).
Shen Yong Q.
Wong Bing L.
Biopure Corporation
Marx Irene
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