Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Preparing oxygen-containing organic compound
Patent
1986-08-07
1990-10-09
Weimar, Elizabeth C.
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Preparing oxygen-containing organic compound
435155, 435244, 4352521, C12P 724, C12P 702, C12N 138, C12N 112
Patent
active
049620274
ABSTRACT:
A method is disclosed for producing 3-hydroxypropionaldehyde (3-HPA) from glycerol by culturing the bacterium Klebsiella pneumoniae having the identifying characteristics of NRRL B-4011, under aerobic conditions, in an aqueous nutrient medium containing glycerol and a compound that causes 3-HPA to be accumulated by blocking the conversion of 3-HPA to trimethylene glycol. This process is particularly useful for the production, from renewable resources, of acrylic acid, an industrially important plymerizable monomer used in the manufacture of synthetic polymers and plastics and which is presently derived from fossil fuel sources.
REFERENCES:
Slininger et al., Appl. and Environ. Microbiol., Jul. 1983, pp. 62-67, vol. 46.
R. H. Abeles, A. M. Brownstein, and C. H. Randles, "B-Hydroxypropionaldehyde, an Intermediate in the Formation of 1,3-Propanediol by Aerobacter aerogenes, " Biochim. Biophys. Acta., 41:530-531 (1960).
P. J. Slininger, R. J. Bothast, and K. L. Smiley, "Production of 3-Hydroxypropionaldehyde from Glycerol," Applied and Environmental Microbiology, 46(1):62-67 (1983).
P. J. Slininger and R. J. Bothast, "Optimizing Aerobic Conversion of Glycerol to 3-Hydroxypropionaldehyde," Applied and Environmental Microbiology, 50(6), 1444-1450 (1985).
Bothast Rodney J.
Slininger Patricia J.
Vancauwenberge James E.
Connor Margaret A.
Marx Irene
Ribando Curtis P.
Silverstein M. Howard
The United States of America as represented by the Secretary of
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