Production of 2′-deoxynucleosides and...

Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives

Reexamination Certificate

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C536S022100, C435S183000

Reexamination Certificate

active

07858775

ABSTRACT:
This invention relates to a process for preparing 2′-deoxynucleoside compounds or 2′-deoxynucleoside precursors using 2-dehydro-3-deoxy-D-gluconic acid (usually abbreviated as KDG) or its salts as a starting material. A variety of 2′-deoxynucleosides and their analogues are used as a starting material for synthesis or drug formulation in production of an antiviral, anticancer or antisense agent.

REFERENCES:
patent: 5759825 (1998-06-01), Wong
patent: 5872247 (1999-02-01), Fleche et al.
De Ley, J. Naturwissenschaften, 1955, 42(4), p. 96.
Candy et al. Biochimica et Biophysica Acta, 1998, 1385, p. 323-338.
CRC Handbook of Chemistry and Physics, Handbook of Chemistry & Physics Online, www.hbcpnetbase.com, accessed online on May 4, 2009.

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