Production of 2,3'-anhydro-2'-deoxyuridine derivatives

Details Production of 2,3'-anhydro-2'-deoxyuridine derivatives Production of 2,3'-anhydro-2'-deoxyuridine derivatives

1988-11-08

1990-06-26

Shen, Cecilia

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

544 95, 544310, C07H 1700

Patent

active

049373293

ABSTRACT:
A process for the production of a 5-substituted derivative of a 2,3'-anhydro-2'-deoxyuridine preferably corresponding to the following general formula: ##STR1## wherein R.sup.1 represents H, alkyl, aryl, halogeno or CF.sub.3 ; characterized in that it comprises heating a 5-substituted derivative of a 2'-deoxyuridine preferably corresponding to the following general formula: ##STR2## wherein R.sup.1 is as defined above; in the presence of a sulphite transfer reagent and preferably a solvent is disclosed.
This process improves the production of valuable intermediates and hence facilitates and reduces the cost of production of pharmacologically-interesting compounds.

REFERENCES:
Dyatkina et al. Chem. Abst. 110-115237q (1989).
Veres et al. Chem. Abst. 110-91126z (1989).
El Kouni et al., Chem. Abst. 109-221912v (1988).
Hayauchi et al., Chem. Abst. 109-211404s (1988).
Sokolova et al. Chem. Abst. 108-38269f (1988).
Rideout et al. Chem. Abst. 107-52002z (1987).
Rideout et al. Chem. Abst. 107-40276d (1987).
Rideout et al. Chem. Abst. 106-38480b (1987).
Davies et al. Chem. Abst. 102-221138c (1985).
Davies et al. Chem. Abst. 101-192379d (1984).
Ajmera et al. Chem. Abst. 100-19719w (1984).
Buchanan et al., Chem. Abst. 90-138134m (1979).
Imazawa et al. Chem. Abst. 89-75431n (1978).
Shibuya et al., Chem. Abst. 88-121666x (1978).
MacCoss et al., Chem. Abst. 88-89968j (1978).
Ozaki, Chem. Abst. 86-5768s (1977).
Glinski, R. P., et al. J. Org. Chem., 38, 4299, (1973).
Michelson, A.M., and Todd, A. R., J. Chem. Soc., 816 (1955).
Fox, J. J. et al., J. Org. Chem., 28, 936 (1963).
Kowollik, E. et al., Tetrahedron Lett., 3863, (1969).
Gerrard, W., J. Chem. Soc., 218, (1940).
Yamazaki, Y., et al, Tetrahedron, 30, 1319, (1974).
Kim, S. et al., et al, Tetrahedron Lett., 27, 1925, (1986).
Staab, H. A. et al., Angew Chem., 73, 26, (1961).

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