Production of 1-.beta.-D-ribofuranosyl-1,2,4-triazole

Details Production of 1-.beta.-D-ribofuranosyl-1,2,4-triazole Production of 1-.beta.-D-ribofuranosyl-1,2,4-triazole

1982-03-09

1984-07-03

Naff, David M.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing compound containing saccharide radical

435118, 435121, 435123, 435126, 435147, 435155, C12P 1928, C12P 1716, C12P 1710, C12P 1704

Patent

active

044580169

ABSTRACT:
The production of a 1-.beta.-D-ribofuranosyl-1,2,4-triazole of the formula ##STR1## wherein R is hydroxy, amino, or alkoxy, is carried out by reacting a 1,2,4 triazole of formula ##STR2## wherein R is hydroxy, amino, or alkoxy group, with a greater than equimolar amount of a ribofuranosyl group donor in the presence of a nucleoside phosphorylase preparation at a temperature in the range from 40.degree. to 65.degree. C. for more than 10 minutes, and recovering a 1-.beta.-D-ribofuranosyl-1,2,4-triazole from the reaction solution. The temperature is preferably from 55.degree. to 65.degree. C. and the time is preferably 10 minutes to 20 hours. An elevated temperature higher than the usual enzyme reaction temperature isused to prevent undesirable enzymatic reactions.

REFERENCES:
patent: 3798209 (1974-03-01), Witkowski et al.
patent: 3856777 (1974-12-01), Ishido et al.
patent: 3935071 (1976-01-01), Bergmeyer et al.
patent: 3976545 (1976-08-01), Witkowski et al.
patent: 4332895 (1982-06-01), Griffiths et al.

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