Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2005-04-26
2005-04-26
Saeed, Kamal (Department: 1626)
Organic compounds -- part of the class 532-570 series
Organic compounds
Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
active
06884892
ABSTRACT:
An epoxytriazole derivative (V) useful as an intermediate for anti-fungal agents and an intermediate therefor having high quality can be produced economically and efficiently by the following industrial means. A compound of the following formula (I) is reacted with trimethyloxosulfonium salt and the like in the presence of a base to give compound (II), this compound is converted to compound (IV), and this compound is reacted with 1,2,4-triazole in the presence of a base.wherein Ar is a phenyl group optionally substituted by 1 to 3 halogen atom(s) or trifluoromethyl group, R is a hydrogen atom or lower alkyl group, and X is a leaving group.
REFERENCES:
patent: 5405861 (1995-04-01), Itoh et al.
patent: 0 061 835 (1982-10-01), None
patent: 0 421 210 (1991-04-01), None
patent: 0 421 600 (1991-04-01), None
patent: 04-356471 (1992-12-01), None
patent: 05-230038 (1993-09-01), None
Honda et al., “A General Synthetic Method of Chiral 2-Arylalkanoic Esters via Thermal 1,2-Rearrangement,”Bull. Chem. Soc. Jpn., 60(3), 1027-1036 (1987).
Tasaka et al., “Optically Active Antifungal Azoles. I. Synthesis and Antifungal Activity of (2R,3R)-2-(2,4-Difluorophenyl)-3-mercapto-1-(1H-1,2,4-triazol-1-yl)-2-butanol and Its Stereoisomers,”Chem. Pharm. Bull., 41(6), 1035-1042 (1993).
Saji et al., “Stereoselective Synthesis of Antifungal Agentthreo-2-(2,4-Difluorophenyl)-3-methylsulfonyl-1-(1H-1,2,4-triazol-1-yl)-2-butanol (SM-8668),”Bull. Chem. Soc. Jpn., 67(5), 1427-1433 (1994).
Tasaka et al., “Optically Active Antifungal Azoles. IV. Synthesis and Antifungal Activity of (2R,3R)-3-Azolyl-2-(substituted phenyl)-1-(1H-1,2,4-triazol-1-yl)-2-butanols,”Chem. Pharm. Bull., 43(3), 432-440 (1995).
Gala et al., “Total Chiral Synthesis of Azole Antifungals via α-Hydroxylation of Ketones,”Tetrahedron Letters, 37(45), 8117-8120 (1996).
Ikemoto Tetsuya
Wang Weiqi
Leydig , Voit & Mayer, Ltd.
Saeed Kamal
Sumitomo Chemical Company Limited
LandOfFree
Production methods of epoxytriazole derivative and... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Production methods of epoxytriazole derivative and..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Production methods of epoxytriazole derivative and... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3374324