Production method of optically active dephenylalanine compounds

Details Production method of optically active dephenylalanine compounds Production method of optically active dephenylalanine compounds

2008-01-22

2008-01-22

Eyler, Yvonne (Department: 1621)

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acids and salts thereof

C562S401000, C562S402000, C546S136000

Reexamination Certificate

active

11498752

ABSTRACT:
Optically active diphenylalanine compounds may be conveniently prepared in a good yield by reacting a diphenylalanine compound represented by formula (1) with an optically active amine compound represented by formula (2) in the presence of an organic solvent to give a diastereomeric salt represented by formula (5) and then treating the diastereomeric salt under acidic conditions to give an optically active diphenylalanine compound represented by formula (3):wherein each symbol is as defined in the specification.

REFERENCES:
patent: 5198548 (1993-03-01), Beylin et al.
patent: 6632816 (2003-10-01), Stranix et al.
patent: 2004/0167341 (2004-08-01), Haffner et al.
patent: 2004/0180928 (2004-09-01), Gutman et al.
patent: 2004/0242636 (2004-12-01), Haffner et al.
patent: 03/002531 (2003-01-01), None
patent: 2004/056764 (2004-07-01), None
Chang et al, “An Efficient Synthesis ofN-BOC-D-Diphenylalanine From A Chiral Azirdine-2-Carboxylate”,Heterocycles, 2002, vol. 57, No. 6, pp. 1143-1148.
Chen et al, “Chiral Synthesis of D- and L-3,3-Diphenylalanine (DIP), Unusualα-Amino Acids For Peptides of Biological Interest”,Tetrahedron Letters, 1992, vol. 33, No. 23, pp. 3293-3296.
H. Chen et al, “Chiral Synthesis of D- and L-3,3-Diphenylalanine (DIP), Unusual α-Amino Acids For Peptides of Biological Interest”,Tetrahedron Letters, 1992, vol. 33, No. 23, pp. 3293-3296.

Affiliated with

Also associated with

Rating

Production method of optically active dephenylalanine compounds does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Production method of optically active dephenylalanine compounds, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Production method of optically active dephenylalanine compounds will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3944534