Production method of optically active dephenylalanine compounds

Details Production method of optically active dephenylalanine compounds Production method of optically active dephenylalanine compounds

2008-01-22

2008-01-22

Eyler, Yvonne (Department: 1621)

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acids and salts thereof

C562S401000, C562S402000, C546S136000

Reexamination Certificate

active

07321055

ABSTRACT:
Optically active diphenylalanine compounds may be conveniently prepared in a good yield by reacting a diphenylalanine compound represented by formula (1) with an optically active amine compound represented by formula (2) in the presence of an organic solvent to give a diastereomeric salt represented by formula (5) and then treating the diastereomeric salt under acidic conditions to give an optically active diphenylalanine compound represented by formula (3):wherein each symbol is as defined in the specification.

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H. Chen et al, “Chiral Synthesis of D- and L-3,3-Diphenylalanine (DIP), Unusual α-Amino Acids For Peptides of Biological Interest”,Tetrahedron Letters, 1992, vol. 33, No. 23, pp. 3293-3296.

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