Production method of heterocyclic mercapto compound

Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

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C549S292000, C546S296000, C548S551000

Reexamination Certificate

active

07902383

ABSTRACT:
A method of the invention industrially produces heterocyclic mercapto compounds useful as raw materials or intermediates in the synthesis of medicaments or pesticides, or as permanent wave agent, with a high yield and high productivity using easily available starting materials. A heterocyclic mercapto compound represented by Formula (1) (wherein X represents any structure of —O—, —S—, —NH—, and —NR1—; R1represents any of an alkyl group, alkoxy group and alkoxyalkyl group each having 1 to 6 carbon atoms; Y represents an oxygen atom, a sulfur atom or —NR2—; R2represents a hydrogen atom or alkyl group having 1 to 6 carbon atoms; and Z1represents a divalent organic residue having at least one mercapto group) is produced by reacting a metal sulfide or a metal hydrosulfide with a compound represented by Formula (2) (wherein X and Y are as defined in Formula (1); and Z2represents a divalent organic residue having at least one halogen group) in the presence of a solvent at a pH of 7.0 to 11.0.

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Miyauchi et al., “Synthesis and Structure-Activity Relationships of a Novel Oral Carbapenem, CS-834,”The Journal of Antibiotics, vol. 50, No. 5, May 1997, pp. 429-439.

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