Production method of alkylated cyanoacetylurea

Details Production method of alkylated cyanoacetylurea Production method of alkylated cyanoacetylurea

1999-05-27

2000-07-18

Richter, Johann

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitriles

C07C25500

Patent

active

060909706

ABSTRACT:
A method for producing alkylated cyanoacetylurea from an easily obtainable starting material. An industrially available cyanoacetylurea and a carbonyl compound are reacted in a polar solvent under reducing conditions to alkylate cyanoacetylurea In addition, a reaction of cyanoacetylurea and acetone under reducing conditions affords isopropylation of cyanoacetylurea.

REFERENCES:
patent: 5003099 (1991-03-01), Mettler et al.
Damewood et al., Journal of Medicinal Chemistry, vol. 37, No. 20, pp. 3303-3312 (1994).

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