Production method of a coupling compound

Details Production method of a coupling compound Production method of a coupling compound

2007-07-03

2007-07-03

Witherspoon, Sikarl A. (Department: 1621)

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acid esters

C568S312000, C568S322000, C568S323000, C568S626000, C570S144000, C558S411000

Reexamination Certificate

active

10781198

ABSTRACT:
There is provided a method for producing a coupling compound of formula (1):in-line-formulae description="In-line Formulae" end="lead"?(Y—)(n−1)R1—R2—(R1)(n′−1)  (1)in-line-formulae description="In-line Formulae" end="tail"?wherein R1, R2n and n′ are as defined below, Y is R2or X as defined below, which method comprises reacting an organic halogen compound of formula (2):in-line-formulae description="In-line Formulae" end="lead"?n′(R1X1n)  (2)in-line-formulae description="In-line Formulae" end="tail"?wherein X1represents a bromine or iodine, R1represents a substituted or unsubstituted, linear, branched or cyclic hydrocarbon group of which α and β carbon atoms in relation to X1are sp3 carbon atoms, n and n′ each independently represent an integer of 1 or 2, and provided that n and n′ do not simultaneously represent 2, with an organic boron compound of formula (3):in-line-formulae description="In-line Formulae" end="lead"?m{R2(BX22)n′}  (3)in-line-formulae description="In-line Formulae" end="tail"?wherein R2represents a substituted or unsubstituted aryl group or a substituted or unsubstituted alkenyl group and the boron atom is bonded with a sp2 carbon atom thereof, X2represents a hydroxyl or alkoxy group, n′ is as defined above, m represents an integer of 1 or 2, and m is not more than n, in the presence of a catalyst comprising a) a nickel compound, andb) b-1) a compound of formula (i):orb-2) a compound of formula (ii):

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