Production method of 4′-bromomethyl-2-cyanobiphenyl

Details Production method of 4′-bromomethyl-2-cyanobiphenyl Production method of 4′-bromomethyl-2-cyanobiphenyl

2005-03-01

2005-03-01

Richter, Johann (Department: 1626)

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitriles

Reexamination Certificate

active

06861549

ABSTRACT:
The present invention relates to a production method of 4′-bromomethyl-2-cyanobiphenyl, which includes reacting 4′-methyl-2-cyanobiphenyl with bromine in the presence of a radical initiator and an oxidant. According to the present invention, since bromine can be regenerated by reacting hydrogen bromide, which is by-produced with the progress of bromination, with an oxidant, inhibition of bromination by hydrogen bromide, coloring by bromine and the like can be prevented. Thus, 4′-bromomethyl-2-cyanobiphenyl useful as a starting material of pharmaceutical products can be produced industrially beneficially.

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