Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Patent
1982-03-23
1984-12-11
Wiseman, Thomas G.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
435 68, 435240, 4351722, 435948, 436548, 424 86, 935110, 935104, 935 92, 260112R, G01N 3354, C12P 2100, C12N 500, A61K 3942
Patent
active
044878290
ABSTRACT:
Monoclonal antibodies, and a cell line characterized by its production of such monoclonal antibodies, demonstrating specific reactivity to an antigenic determinant possessed by a plurality of types of adenoviruses, a method of isolating such cell lines, and the use of such antibodies for diagnostic and therapeutic purposes as well as for identifying chemical compounds with similar properties, are disclosed.
REFERENCES:
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patent: 4196265 (1980-04-01), Koprowski et al.
Russel et al., "Monoclonal Antibodies Against Adenovirus Type 5: Preparation and Preliminary Characterization" Journal of General Virology 56 (10-1980) pp. 393-408.
Philipson et al., "Reproduction of Adenoviruses" Comprehensive Virology, vol. 3, (1974), pp. 143-227.
David et al., "The Hybridoma--An Immunochemical Laser" Clinical Chemistry 27 (9) (1981), pp. 1580-1585.
Noonan et al., "Application of Monoclonal Antibodies to Study the Distribution of Cell Surface Proteins: Prospects and Problems" Monoclonal Antibodies in Endocrin Research, Raven Press, (1981), pp. 41-52.
Foy et al., "Adenoviruses" in Viral Infections of Humans, by Evans, Plenum Medical Book Co., NY, (1976), pp. 53-55.
Cepko et al., "Immunoprecipitation with Two Dimensional Pools as a Hybridoma Screening Technique: Production and Characterization of . . . " Virology 110 (1981), pp. 385-401.
Herzenberg et al., "Cell Hybrids of Myelomas with Antibody Forming Cells and T-Lymphomas with T Cells" Handbook of Experimental Immunology, Blackwell Publ., pp. 25.1-25.7.
Kohler et al., "Continuous Cultures of Fused Cells Secreting Antibody of Predefined Specificity" Nature 256 (8-1975), pp. 295-297.
Galfry et al., "Antibodies to Major Histocompatibility Antigens Produced by Hybrid Cell Lines" Nature vol. 266 (1977) pp. 550-552.
Nowinski et al., "Mapping of Viral Proteins with Monoclonal Antibodies" Monoclonal Antibodies: Hybridoma: A New Dimension in Biological Analysis Kennet et al., ed. Plenum Press NY (1980) part 5, pp. 295-359.
Cuello et al., "Detection of Substance P in the Central Nervous System by a Monoclonal Antibody" Proceedings of the National Academy of Sciences, 78(7) (1979), pp. 3532-3536.
Cepko Constance L.
Changelian Paul
Sharp Phillip A.
Engellenner Thomas J.
Massachusetts Institute of Technology
Smith, Jr. Arthur A.
Tarcza John E.
Wiseman Thomas G.
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