Production and use of in situ-modified nanoparticles

Details Production and use of in situ-modified nanoparticles Production and use of in situ-modified nanoparticles

2003-12-06

2008-03-18

Le, Long V. (Department: 1641)

Chemistry: analytical and immunological testing

Involving an insoluble carrier for immobilizing immunochemicals

Carrier is particulate and the particles are of...

C436S525000, C436S056000, C436S080000, C436S081000, C436S082000, C977S810000, C977S811000, C530S405000

Reexamination Certificate

active

07344895

ABSTRACT:
A process for synthesizing nanoparticles, in particular metal salt nanoparticles. To the synthesis mixture is added a modifying reagent which binds, by means of a first functional group, to the nanoparticle surface and which carries a second functional group for binding to molecules which are specifically selected in dependence on the subsequent use of the nanoparticles. This dispenses with a postsynthetic, separate, application-specific modification step. A new substance class, the pentaalkyl iminobis(methylenephosphono)carboxylates, are particularly suitable for this purpose. These modifying reagents permit the nanoparticles to grow in a specifically controlled manner and, at the same time, modify the surface of the growing nanoparticles, (in-situ) during the synthesis, such that the particles can be very readily dissolved in a large number of solvents and carry functional groups for coupling on molecules, resulting in the particles having, immediately after having been synthesized, a certain all-round usability.

REFERENCES:
patent: 2003/0032192 (2003-02-01), Haubold et al.
patent: 2004/0014060 (2004-01-01), Hoheisel et al.
patent: 0 672 673 (1995-09-01), None
patent: WO 02/20696 (2002-03-01), None
ANON; “Derivaties of aminomethylphosphonic acid”; Research Disclosure (1979); p. 177; XP002277288.

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