Production and use of imines of porphyrins, of porphyrin derivat

Details Production and use of imines of porphyrins, of porphyrin derivat Production and use of imines of porphyrins, of porphyrin derivat

1993-11-24

1995-06-13

Shah, Mukund J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

540145, 534 11, 534 12, A61K 3140, C07D48722

Patent

active

054243050

ABSTRACT:
Purified imines of porphyrins, chlorins, bateriochlorins, chlorophylls, bacteriochlorophylls, purpurins, reduced purpurins, verdins, Diels Alder adducts, benzochlorins and metal complexes of the foregoing imines are disclosed for retarding growth of cancer tumors such as bladder tumors. The formulas of the benzochlorinimines and of the benzochlorinimine metal complexes are set forth below: ##STR1## In specific examples, M in the metal complexes is a copper cation that is complexed with two of the nitrogens of the benzochlorinimine R' and R"" are methyl, and R1 through R8 are ethyl.

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