Production and use of anti-dorsalizing morphogenetic protein

Details Production and use of anti-dorsalizing morphogenetic protein Production and use of anti-dorsalizing morphogenetic protein

1994-11-08

1997-12-02

Jagannathan, Vasu S.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

530399, 930120, 514 12, C07H 2104, C07K 1451, C12N 1512, A61K 3818

Patent

active

056937792

ABSTRACT:
An isolated polynucleotide of anti-dorsalizing morphogenetic protein (ADMP-1) is obtained from Xenopus. The protein is most closely related to human BMP-3. ADMP-1 functions as a modulator for dorsalizing influences, and prevents syndromes involving inappropriate proliferation of tissues.

REFERENCES:
patent: 5279966 (1994-01-01), Jessell et al.
Harland et al "The Transforming Growth Factor .beta. Family . . . " PNAS 91(22):10243-10246 (Oct. 1994).
Basler et al, "Control of Cell Pattern in the Neural Tube . . . " Cell 73:687-702 (May 1993).
Christian et al, "Xwnt-8 Modifies the Character of Mesoderm . . . " EMBO J 11(1):33-4 (1992).
Smith et al, "Injected Xwnt-8 RNA Acts Early in Xenopus . . . " Cell 67:753-765 (Nov. 1991).
Berkow et al, The Merck Manual, pp. 1387-1388, 1606-1607, 1961-1962.

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