Production and use of antheimintic agents and protective antigen

Details Production and use of antheimintic agents and protective antigen Production and use of antheimintic agents and protective antigen

1992-08-14

1995-05-16

Furman, Keith C.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Parasitic organism or component thereof or substance...

530350, 530412, 530416, 530417, 530418, 530422, 530427, 530806, C07K 1508, C07K 322, C07K 328, A61K 3900

Patent

active

054158591

ABSTRACT:
The protein doublet H110D, the individual components thereof, and the production and use thereof in a vaccine against a nematode infection. This protein doublet is a plasma membrane-associated protein material of the intestinal microvilli of Haemonchus contortus. H110D has a molecular weight of about 110 kd and reacts with antibodies raised in animals injected with a contortin-enriched fraction. Injection of preparations of the protein doublet H110D or its components induces the production of specific protective antibodies.

REFERENCES:
patent: 3395218 (1968-07-01), Silverman
Emery et al., 1991, Parasitology, Today, 7(12):347-349.
Salem et al., 1984, J. Biol. Chem., 259(19):12246-12251.
Martin et al., 1986, J. Biol. Chem. 261(19):8754-8760.
Clarke et al., 1984, Abstract of Can. J. Comp. Med., 48(2):166-170, Biological Abstract, vol. 78, No. 59955.
E. A. Munn et al., Parasitology (1987), 94:385-397, Vaccination of young lambs by means of a protein fraction extracted from adult Haemonchus contortus.

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