Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...
Patent
1994-10-03
1997-03-18
Scheiner, Toni R.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Blood proteins or globulins, e.g., proteoglycans, platelet...
436547, 424450, 4241841, C07K 1600
Patent
active
056124597
ABSTRACT:
The present invention relates to antiteicoplanin polyclonal antibodies raised against a composition consisting of teicoplanin encapsulated in negatively-charged liposomes and the antibodies are not immunoreactive with any other antibiotics. The present invention relates to a method for determining the amount of teicoplanin in a biological sample, which comprises the steps of a) incubating anti-teicoplanin antiserum of the present invention with a biological sample containing an unknown amount of teicoplanin on a solid support; b) incubating anti-teicoplanin polyclonal antibodies of the present invention in serum with a standard containing a known amount of teicoplanin on a solid support; and c) determining the presence or absence of agglutination in step a) and b) whereby determining the unknown amount of teicoplanin present in the biological sample by comparing with the complete inhibition of agglutination of step b).
REFERENCES:
Aguado et al., Immunobiol. vol. 184, pp. 113-125 (1992).
Bradford, M., "A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding", Analytical Biochemistry 72, pp. 248-54 (1976).
Szoka, F., Jr. et al, "Procedure for Preparation of Liposomes with Large Internal Aqueous Space and High Capture by Reverse-Phase Evaporation", Proc. Natl. Acad. Sci. USA., vol. 75, No. 9, pp. 4194-98, Sep. 1978.
Bangham, A.D., et al, "Preparation and Use of Liposomes as Models of Biological Membranes", Methods in Membrane Biology, vol. 11, 1974, pp. 1-68.
Ravaoarinoro M. et al., 91st ASM Abstract A-130, 1991.
Ravaoarinoro Madeleine
Toma Emil
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