Product removal process for use in a biofermentation system

Details Product removal process for use in a biofermentation system Product removal process for use in a biofermentation system

2007-01-23

2007-01-23

Lilling, Herbert J. (Department: 1651)

Chemistry: molecular biology and microbiology

Apparatus

Bioreactor

C210S198100, C210S198200, C210S656000, C210S675000, C210S676000, C210S767000

Reexamination Certificate

active

10860221

ABSTRACT:
This invention relates to a bioprocess engineering solution for a product removal process for use in a biofermentation. The invention discloses a process for withdrawing an aliquot of broth from a biofermentation vessel during at least a portion of the biofermentation, removing biocatalyst and water, chromatographically separating biofermentation products from the withdrawn broth using water as an eluent, and returning the remaining components of the broth back to the biofermentation vessel. Process chromatography permits highly selective separation of the target molecule, preventing feedback inhibition of the biofermentation.

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