Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1994-05-26
1996-04-09
Chan, Christina Y.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
514 12, 530324, 530350, 530360, 530365, 530832, 424535, A61K 3800, A61K 3520, C07K 100
Patent
active
055062091
ABSTRACT:
The infection of mammalian cells by RSV may be inhibited by native human .beta.-casein, a recombinant form of human .beta.-casein, and hydrolysates of both. The human .beta.-casein or hydrolysate may be contained in a liquid enteral nutritional product such as an infant formula. The enteral nutritional product may be used, for example, in the prevention and treatment of respiratory tract infection in infants. The human .beta.-casein or hydrolysate may also be administered as a throat spray or nasally using drops or a spray.
REFERENCES:
Svanborg et al., Adv. Exp. Med. Biol., 310:167-171 (1991).
Tyrell, "Breast Feeding and Virus Infection", The Immunology of Infant Feeding, ed. A. W. Wikinson, Plenum Press, pp. 55-62 (1981).
Anderson et al., "Microneutralization Test for Respiratory Syncytial Virus Based on an Enzyme Immunoassay", Journal of Clinical Microbiology, 22:1050-1052 (1985).
Laegreid et al, Acta Pediatrica Scandanvica, vol. 75, pp. 696-701, 1986.
"Respiratory Syncytial Virus or Influenza in Adults", Pediatric Notes, 18(4):1 (1994).
Anianson et al., "Anti-adhesive Activity of Human Casein Against Streptococcus pneumoniae and Haemophilus influenzae", Microbial Pathogenesis, 8:315-323 (1990).
Hannson et al., "Expression of Human Milk B-Casein in Escheria coli: Comparison of Recombinant Protein with Native Isoforms", Protein Expression and Purification, 4:373-381 (1993).
Lonnerdal et al., "Cloning and Sequencing of a cDNA Encoding Human B-Casein", Federation of European Biochemical Society Letters, 269(1):153-156 (1990).
Okamoto et al., "Antiviral Factors in Human Milk: Implications in Respiratory Syncitial Virus Infection", Acta Paediatrica Scandinavica Supplement, 351:137-143 (1989).
Laegrid et al., "Neutralizing Activity in Human Milk Fractions Against Respiratory Syncytial Virus", Acta Paediatirica Scandanavica, 75:696-701 (1986).
Anderson Steven N.
Mukerji Pradip
Schaller Joseph P.
Seo Amanda E.
Abbott Laboratories
Chan Christina Y.
Drayer Lonnie R.
Mohamed Abdel A.
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