Product for inhibition of human rotavirus infection

Details Product for inhibition of human rotavirus infection Product for inhibition of human rotavirus infection

1996-10-15

1998-01-27

Wax, Robert A.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 2, 514 8, 514 21, 435 691, 426657, 530360, A61K 3800, A61K 3816, C12P 2106, A23J 102

Patent

active

057122504

ABSTRACT:
An enteral nutritional product containing either bovine .kappa.-casein or human .kappa.-casein at a concentration greater than that found in human or bovine milk and sufficient to inhibit infection of mammalian cells by human rotavirus.

REFERENCES:
patent: 5147853 (1992-09-01), Dosako et al.
patent: 5260280 (1993-11-01), Isoda et al.
patent: 5505955 (1996-04-01), Peterson et al.
patent: 5576300 (1996-11-01), Mukerji et al.
Brignon et al. (1985) Preparation and amino acid sequence of human kappa-casein, FEBS Letters 188 (1): 48-54, Aug. 1985.
Kitamoto et al., "Comparative Growth of Different Rotavirus Strains in Differentiated Cells (MA 104, HepG2, and CaCo-2)", Virology, 184:729-737 (1991).
Yolken et al., "Human Milk Mucin Inhibits Rotavirus Replication and Prevents Experimental Gastroenteritis", Journal of Clinical Investigation, 90:1984-1991 (1992).
Salf et al., "Cell culture propagation or a rotavirus," J. of Tissue Culture Methods: 149-156, 1988.
Terrett et al., "Physiochemical characterization of porcine pararotavirus & detection of virus & viral antibodies using cell culture immunofluorescence," J. of Clinical Microbiology 25:268-272, 1987.

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