Product for inhibition of attachment of H. influenzae to human c

Details Product for inhibition of attachment of H. influenzae to human c Product for inhibition of attachment of H. influenzae to human c

1994-05-26

1997-07-01

Tsang, Cecilia

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 12, 530324, 530350, 530360, 530365, 530832, 424535, A61K 3800, C07K 100

Patent

active

056438800

ABSTRACT:
The attachment of H. influenzae to human cells, such as oropharyngeal cells, may be inhibited by native human .beta.-casein, a recombinant form of human .beta.-casein, and hydrolysates of both. The human .beta.-casein or hydrolysate may be contained in a liquid enteral nutritional product such as an infant formula. The enteral nutritional product may be used, for example, in the prevention and treatment of otitis media in infants. The human .beta.-casein or hydrolysate may also be administered as a throat spray or nasally using drops or a spray.

REFERENCES:
Svanborg, et al., Adv. Exp. Med. Biol., 310:167-171 (1991).
Bakaletz et al., "Frequency of Fimbriation of Nontypable Haemophilus influenzae and it's Ability to Adhere to Chinchilla and Human Respiratory Epithelium", Infection and Immunity, 56(2):331-335 (1988).
Morse et al., "Haemophilus", Microbiology, 4th ed., Ed. by Davis et al., J.B. Lippincott Co., 615-618(1990).
Harada et al., "Adherence of Haemophilus influenzae to nasal, nasopharyngeal and buccal epithellial cells from patients with otitis media", European Archives of Oto-Rhino-Laryngology, 247:122-124 (1990).
Anianson et al., "Anti-adhesive activity of human casein against Streptococcus pneumoniae and Haemophilus influenzae ", Microbial Pathogenesis, 8:315-323 (1990).
Lonnerdal et al., "Cloning and Sequencing of a cDNA encoding human milk B-Casein", Federation of European Biochemical Societies Letters, 269(1):153-156 (1990).
Stephens et al., "Pathogenic Events During Infection of the Human Nasopharynx with Niesseria meningitidis and Hemophilus influenzae", Reviews of Infectious Diseases, 13:22-33 (1991).
Stenfors et al., "Abundant Attachment of Bacteria to Nasopharyngeal Epithelium in Otitis-Prone Children", Journal of Infectious Diseases, 165:1148-1150 (1992).
Takahashi et al., "Phosphorylation of a Surface Receptor Bound Urokinase-Type Plasminogen Activator in a Human Metastatic Carcinomatous Cell Line", Biochemical and Biophysical Research Communications, 182 (3):1466-1472 (1992).
Sheard,"Breast Feeding Protects Against Otitis Media", Nutrition Reviews, 51(9): 275-277 (1993).
Duncan et al., "Exclusive Breast Feeding for at Least 4 Months Protects Agianst Otitis Media", Pediatrics, 91(5):867-872 (1993).
Hansson et al., "Expression of Human Milk B-Casein in Escheria coli; Comparison of Recombinant Protein with Native Isoforms", Protein Expression and Purification, 4:373-381 (1993).
Ardehali et al., "Indium labeling of microorganisms to facilitate the investigation of bacterial adhesion", Journal of Biomedical Materials Research, 27:269-275 (1993).

Affiliated with

Also associated with

Rating

Product for inhibition of attachment of H. influenzae to human c does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Product for inhibition of attachment of H. influenzae to human c, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Product for inhibition of attachment of H. influenzae to human c will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-597162