Product derived from milk substantially free of beta casein...

Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Casein or caseinate

Reexamination Certificate

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C514S012200

Reexamination Certificate

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07091320

ABSTRACT:
The present invention is related to a product derived from milk, substantially free of beta casein from non-human mammals. The invention is also related to the use of such a product especially in relation to diet, more particularly for early infancy, in the prevention of insulin-dependent diabets.

REFERENCES:
patent: 6451368 (2002-09-01), Elliott et al.
patent: WO 9304172 (1993-03-01), None
Lönnerdal et al. Cloning and Sequencing of a cDNA Encoding Human Milk Beta-Casein. FEBS Letters. Aug. 1990. vol. 269, No. 1, pp. 153-156.
209 amino acid sequence of Beta-casein A1 variant from Bovine taurus: Accession code: 1314242A.
224 amino acid sequence of Beta-casein A2 variant from Bovine taurus: Accession code: NP—851351..
226 amino acid sequence of Beta-casein from Homo sapiens: Accession code: NP—001882.
Greiner. History of Breastfeeding. The Nursing Mothers' Asociation of Australia Christmast Newletter. 1998. vol. 34, No. 6, pp. 4-5.
Akerblom et al. Dietary manipulation of beta cell autoimmunity in infants at increased risk to type 1 diabetes: a pilot study. Diabetologia. 2005. vol. 48, pp. 829-837.
Healthcare Professional Resource Center: Enfamil, Nutramigen, LIPIL. Hypoallergenic Protein Hydrolysate Formula. www.meadjohnson.com/professional/products
utramigenlipil.html.
H.K. Akerblom, “The Case for Elimination of Cow's Milk in Early Infancy in the Prevention of Type 1 Diabetes: The Finnish Experience” Diabetes/Metabolism Reviews, vol. 9, No. 4, pp. 269-278 (1993) by John Wiley & Sons, Ltd., Helsinki, Finland.
Denis Daneman, et al “Dietary Triggers of Insulin-Dependent Diabetes in the BB Rat” Diabetes Research pp. 93-97 (1987) Teviot-Kimpton Publications, Toronto, Canada.
R. B. Elliot, et al “Dietary Triggers of Diabetes in the NOD Mouse” Frontiers in diabetes research. Ed E. Shafrir. III 4 pp. 195-197. (1990).
R.B. Elliot, et al Dietary Protein: a Trigger of Insulin-Dependent Diabetes in the BB Rat? Research Institute Diabetologia Springer-Verlag (1984) vol. 26: pp. 297-299.
R.B. Elliot, et al “Dietary Prevention of Diabetes in the Non-obese Diabetic Mouse” Diabetologia Springer-Verlag (1988) vol. 31: pp. 62-64.
Julio M. Martin, et al “Milk Proteins in the Etiology of Insulin-Dependent Diabetes Mellitus (IDDM)” Annals of Medicine vol. 23: pp. 447-452 (1991).
S. Reddy, et al “A Combined Casein-Free-Nicotinamide Diet Prevents Diabetes In the NOD Mouse With Minimum Insulities” Diabetes Research and Clinical Practice vol. 29 pp. 83-92 (1995).
Suvi M. Virtanen, et al “Early Introduction of Dairy Products Associated with Increased Of Risk of IDDM in Finnish Children” Diabetes vol. 42 pp. 1786-1790 (1993).
Luis Castano, et al “Type I Diabetes: A Chronic Autoimmune Disease of Human, Mouse, and Rat” Annual Reviews Immunol., vol. 8 pp. 647-679 (1990).
Hertzel C. Gerstein “Cow's Milk Exposure and Type I Diabetes Mellitus” Diabetes Care, vol. 17 No. 1, pp. 13-19 (1994).
Faser W Scott Cow Milk and insulin-dependent diabetes mellitus: is there a relationship? American Society for Clinical Nutrition, vol. 51 pp. 489-491 (1990).
G. Dahlquist, et al “An increased level of antibodies to beta-lactoglobulin is a risk determinant for early onset Type I diabetes mellitus independent of islet cell and antibodies and early introduction of cow's milk” Diabetologia, vol. 35, pp. 980-984 (1992).
Knul Dahl-Jorgensen, et al “Relationship Between Cow's Milk Consumption and Incidence of IDDM in Childhood” Diabetes Care vol. 14 No. 11, pp. 1081-1083 (1991).
R.B. Elliot, et al “Prevention of Delay of Type I (Insulin-dependent) diabetes mellitus in children using nicotinamide” Diabetologia, vol. 34 pp. 362-365 (1996).
Pediatr. Adolesc. Endocrinol. Basel, Karger 1993. vool.23, pp. 97-104.
Diabetologia 1993:36: EASA News Section pp. 51-53.

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